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KMID : 0895820170270020019
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Journal of Oriental Rehabilitation Medicine
2017 Volume.27 No. 2 p.19 ~ p.27
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Effects of Bia-hwan (Feier-wan) on the Ovariectomized Rat Model of Osteoporosis
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Cho Chang-Young
Kim Dong-Hee
Kim Sang-Bae
Yang Kyu-Jin
Sohn Young-Joo
Kim Eun-Young
Kim Min-Beom
Jung Hyuk-Sang
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Abstract
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Objectives : Osteoporosis is a common disease in adults with prevalence rate of more than 40%, and occurs more to female than to male. The purpose of this study is to identify the effect of Bia-hwan (Feier-wan) on the osteoporosis of ovariectomized rats.
Methods : 24 female rats were randomly assigned to a SHAM group, a control group, and a BAH group. Ovaries of the control group and the BAH group were extracted. After than, general animal feed were given to the SHAM group and the control group, animal feed contained BAH were given to the BAH group through mouths of them. After 8 weeks, rats were
sacrificed and their weight, calcium, phosphorus, estradiol, total-cholesterol, triglyceride, ALP, albumin, AST, ALT, the weight of femur and tibia ash per body ratio, both area and thickness of trabecular bone, the area of osteoblast and the number of osteoclast were measured.
Results : The level of calcium, phosphorus, AST in the serum of the BAH group increased significantly compared to the control group. There was no significant difference between the control group and the BAH group in the level of estradiol, total-cholesterol, triglyceride, ALP, albumin, and ALT in the serum. There was no significant difference between the control group and the BAH group in the weight of femur and tibia ash per body ratio. The thickness of trabecular of the BAH group increased significantly compared to the control group, but there was no significant difference in the trabecular area. The area of osteoblast and the number of osteoclast of the BAH group decreased significantly compared to the control
group.
Conclusions : From the results of the above study, oral intake of BAH can inhibit the decrease of calcium, phosphorus in blood and prevent the thinning process of the trabecular by suppressing activation of osteoclast. Thus, BAH may have effects on the treatment and prevention of osteoporosis.
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KEYWORD
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Bia-hwan (Feier-wan), Ovariectomy , Osteoporosis , Osteoclast , Trabecular thickness
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